Mirza was born to a sports journalist Imran Mirza and Nasima in Mumbai. She was brought up in Hyderabad. Mirza began playing tennis at the age of six, turning professional in 2003. She was trained by her father, as well as her other family members and was sponsored by the industrialist GV Krishna Reddy. She went to Nasr school in Hyderabad.And later joined St.Mary's college for her graduation.
Mirza won the 2003 Wimbledon Championships Girls' Doubles title, teaming up with Alisa Kleybanova of Russia.